Affect on GABA function

• GABA is major inhibitory neurotransmitter

• Alcohol Potentiates GABA receptor function

• GABA receptor is site of action of sedative/anesthetic barbiturate, pentobarbitol

• GABA receptor is site of action of sedative/anxiolytic benzodiazipines

• Major Site of Affects include:

  • medial septal nucleus -- controls “arousal state”
  • Purkinje neurons in cerebellar cortex -- controls sensory and motor activity

• RO 15-4513 overcomes motor impairment

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