Metabolic Differences Between Ethnic Groups
Isoenzymes in Alcohol DH (ADH)
- Beta1 in Caucasian has Km 0.00023 g/dL
- Beta2 in Asian has Km 0.0043 g/dL
- Beta3 in 15% African Amer. has Km .165 g/dL
50% Asian have inactive mito. Aldehyde DH (ALDH) resulting in facial flushing, palpitations, dizziness, and nausea