Variations in Metabolic Capabilities

• Isoenzymes in Alcohol DH (ADH)

  • Beta1 in Caucasian has Km 0.23 mg%
  • Beta2 in Asian has Km 4.3 mg%
  • Beta3 in 15% African Amer. has Km 165 mg%

• Gastric ADH low in women

• 50% Asian have inactive mito. Aldehyde DH (ALDH) resulting in facial flushing, palpitations, dizziness, and nausea

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