Sedation

• Long-Sleep/Short-Sleep mice

  • differ by righting reflex
  • LS loose righting reflex with 1/2 the alcohol level of SS
  • LS looses righting reflex with 1/30 the alcohol when admin. to Purkinge cells

• Biochemical Differences

  • LS more sensitive to alcohol augmentation of GABA function
  • GABA receptor in LS mice has enhanced alcohol activation-- frog oocyte gene transfer

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