Withdrawal/Dependence
Withdrawal-Seizure Prone(WSP) and Withdrawal-Seizure Resistant(WSR) mice
- 10x more severe symptoms
- no difference in sensitivity to other affects of alcohol including tolerance
Biochemical Differences
- Must be Genetic Component to Dependence
- Glutamate receptors increase with alcohol consumption
- WSP have more hippocampal NMDA (glutamate) receptors